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Researchers and rheumatologists refer to a window of opportunity when treating a patient with rheumatoid arthritis that offers the best chance of a successful treatment outcome. They are referring to early rheumatoid arthritis. What exactly is early rheumatoid arthritis? 
Late-onset neutropenia following treatment with rituximab (also known as Rituxan) is a known side effect in lymphoma patients. There have only been a few cases of the adverse reaction in autoimmune disease patients. 
Patients who have had an unsatisfactory response to DMARDs (disease-modifying anti-rheumatic drugs), either alone or in combination with other arthritis medications, are usually good candidates for biologics. 
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